Job Description
The Associate Scientist will report to the Director Drug Discovery and Validation in the Research and Drug Discovery group. The candidate will be responsible for designing and executing experimental systems for functional validation of novel immunomodulatory molecules discovered by Compugen, including target validation activities, research tools generation and QC, expression studies, Abs characterization, cell-based assays, and ELISA establishment. The candidate will be responsible for planning and conducting experiments, recording, and analyzing data, presenting results to management, and writing research reports. The candidate is expected to demonstrate creative/out of the box thinking, propose original solutions to complex problems, perform hands-on experimental work and be an excellent team player.
- Perform different biochemical assays for antibody characterization (Western blot, ELISA, flow cytometry)
- Perform cell based functional assays
- Perform antibody based in vitro assays
- Perform different analytical method for protein characterization
- Generate over expression systems and knock-down/knockout cells
- Record results in laboratory notebook, prepare written reports and oral presentations in a timely manner
- Collaborate with team members to ensure timely progress of research projects according to pipeline prioritization
- Temporary position for a year
Job Requirements
- MSc in Life Sciences with at least 2 years of experience in the biotech industry
- Highly experience in biochemical technologies – Western blot, ELISA – must
- Highly experience in molecular biology methods –must
- Highly experienced in cell culture technologies – mus
- Over expression systems (lentivirus, , transfections etc.) including single clone generation and characterization, cell soring
- knock-down/knock out technologies (si/shRNA, CRISPR)
- Experience in protein analytical methods (HPLC, Biacore) – advantage
- Experience in protein/ antibody production
- Extensive experience in cell based in vitro assays
- Experience in FACS staining
- Antibody based in vitro assays
- Cell based functional assays
- Knowledgeable in monoclonal Ab discovery – advantage
- Excellent written and verbal communication skills (English)
- Ability to prioritize and manage multiple projects and activities
- Ability to work independently; proactively address issues and troubleshoot problems
