Principal Scientist

Job Description

The Principal Scientist will report to the Director Drug Discovery and Validation in the Research and Drug Discovery group.
The Principal Scientist will be responsible for coordinating all protein science activities, including working with CROs and selecting therapeutic antibodies. The candidate will lead multidisciplinary activities in the field of protein science ranging from early R&D development through pre-clinical validation, contributing their expertise to all projects in the pipeline.
The candidate is expected to demonstrate creative/out of the box thinking, propose original solutions to complex problems, establish new capabilities and provide scientific leadership to biochemical characterization of protein and antibodies in the group.

  • Lead scientifically and manage all protein science related activities (both internal and via CRO management)
  • Lead Ab discovery activities via CRO management
  • Develop different biochemical assays for antibody characterization
  • Perform and lead antibody and protein production in house
  • Establish SPR capabilities in house
  • Collaborate with team members to ensure timely progress of research projects according to pipeline prioritization

Job Requirements

  • PhD in Life Sciences with minimum 6 years’ experience in the biotech industry
  • Experience manage CROs and provides guidance and direction to achieve tasks
  • Highly experienced in protein engineering, protein expression and purification – must
  • Highly experienced in protein analytical methods – Biacore, HPLC– must
  • Highly experience in biochemical technologies – ELISA, Western blot – must
  • Experience in molecular biology methods – must
  • Knowledgeable in protein- protein interaction – must
  • Knowledgeable in monoclonal antibody discovery – highly desired
  • Experienced in cell culture technologies – an advantage
    • Over expression systems (lentivirus, transfections etc.) including single clone generation and characterization, cell soring
    • knock-down/knock out technologies (si/shRNA, CRISPR)
  • Experience in cell based in vitro assays – an advantage
    • Experience in FACS staining
  • Excellent written and verbal communication skills (English)
  • Ability to prioritize and manage multiple projects and activities
  • Ability to work independently; proactively address issues and troubleshoot problems

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